Obesity Overview

Together With

It is difficult to systematically beat the market. But it is not difficult to systematically throw money down a rat hole by generating commissions (and other costs).

— Michael Jensen

Research

GMO shares where they see opportunity if you are willing to look different than a standard, capitalization-weighted 60/40 portfolio.

Deutsche Bank covers the five AI themes below and what they suggest about the future of AI.

  1. AI is the elephant in the stock room

  2. Data centers are AI Ground Zero

  3. AI is still a magnet for funding

  4. Political appetite is growing for AI regulation

  5. Real-world uses have yet to emerge at scale

As of September 11, 2024

Stifel published a huge research piece on the emerging market for pharmaceutical products for obesity, the consumerization of obesity drug buying via online telelhealth, and the secondary and tertiary effects of weight loss.

As of July 8, 2024

Facts & Figures

The pharma industry currently accounts for about 70% of GDP growth in Denmark. Link

Apple’s 2023 revenue (almost $400 billion) makes it about as big as the entire economy of Denmark or the Philippines. Link

The median age of all U.S. homebuyers is now 49 years old, up from 31 in 1981. Link

BlackRock has returned an average of 20.7% per year since its IPO in 1999, outperforming the S&P 500, the Nasdaq 100, Amazon and Microsoft. Link

Millennium has generated $56 billion in gains for investors after fees since the firm’s inception in 1989. Link

Ed Yardeni highlights past geopolitically-induced selloffs tended to be buying opportunities.

As of October 1, 2024

Investing regardless of the party has far outpaced investing for only Democrats or Republicans. Link

Given the substantial contribution of healthcare and government jobs to overall payroll growth over the past year, a slowdown in these categories could lead to a further deceleration in job gains.

Default rate by year for global sovereign bonds, emerging market corporate high yield bonds, and U.S. corporate high yield bonds. Link

Where Sophisticated Investors Access Private Markets

For individual investors, sourcing and vetting high-quality, sub-scale private market opportunities poses challenges – information asymmetry, adverse selection, insufficient resources, etc.

Enter 10 East.

10 East, led by Michael Leffell, is a platform where qualified investors can invest in vetted private credit, real estate, niche venture/private equity, and other one-off investments that aren’t typically available through traditional channels.

10 East principals have a 12+ year track record of strong performance across 355+ transactions.

And the best part? 10 East offers the flexibility to invest on a deal-by-deal basis, while co-investing alongside industry veterans who have skin-in-the-game.

10 East is where founders, executives, and portfolio managers from leading firms are diversifying their personal wealth.

Podcasts

9/12/24 - 50 minutes

Pejman Nozad and Jason Shuman, two VC’s, each give presentations on their strategies & the role power laws play in good and great VC funds.

9/20/24 - 60 minutes

Botha discusses his career, Sequoia’s culture and investment processes, and how he finds and builds enduring businesses.

What Else Is Happening

Deal of the Week

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